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This article discusses the genetic factors behind high gamma glutamyl transpeptidase levels.

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What is gamma glutamyl transpeptidase?

Gamma glutamyl transpeptidase (GGT) is an enzyme found in the liver, pancreas, and kidneys that plays a role in the metabolism of glutathione, a powerful antioxidant. GGT is commonly measured in blood tests to assess liver function and diagnose liver diseases.

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What are the potential causes of high levels of gamma glutamyl transpeptidase?

Elevated levels of GGT can have several possible causes, including liver diseases such as hepatitis, alcohol abuse, certain medications, obesity, and even genetics. Identifying the underlying cause is important in order to determine the appropriate treatment and manage the condition effectively.

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FAQ (Frequently Asked Questions)


Can genetics influence the levels of gamma glutamyl transpeptidase?

Yes, genetics can indeed play a role in determining the levels of GGT in an individual. Studies have shown that certain genetic variations can predispose some people to have higher levels of GGT. However, it is important to note that genetics is just one of the factors influencing GGT levels and other environmental or lifestyle factors also contribute to its elevation.

Are high levels of gamma glutamyl transpeptidase always a sign of liver disease?

No, although elevated GGT levels often indicate liver dysfunction, they are not always a direct sign of liver disease. GGT can also be increased due to other factors such as excessive alcohol consumption, certain medications, obesity, or even strenuous physical activity. Therefore, it is necessary to conduct further tests and evaluations to establish a proper diagnosis.

How can high levels of gamma glutamyl transpeptidase be managed or treated?

The management or treatment of elevated GGT levels depends on the underlying cause. If liver disease is the cause, it is important to address and treat the specific liver condition. Lifestyle changes such as reducing alcohol intake, maintaining a healthy weight, and avoiding certain medications may also be recommended. In some cases, medications to lower GGT levels might be prescribed, but the overall treatment approach should be tailored to the individual's unique situation.

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